Le Dung, DT Thien, NT Dong, TTY Nhi, NT An, M Rinaudo, M Milas

Many water-soluble N-substituted chitosan derivatives have been prepared having the typical -NH-CH₂- linkage. Both the Michael reaction and alkylation with monochloroacetic acid at pH 8 - 8.5 offer relatively simple ways for their synthesis.

Keywords: N-carboxymethyl chitosan; N-dicarboxymethyl chitosan; N-carboxyethyl chitosan; N-carboxybutyl chitosan; N-trimethyl chitosan; 5-methylpyrolidinone chitosan

AJSTD Vol.22(3) pp.261-270 (2005)